Acetals of lactams and amides of acids. Communication 78. Synthesis and biological activity of 7,8-polymethylenepurine derivatives
Identifieur interne : 001D66 ( Main/Exploration ); précédent : 001D65; suivant : 001D67Acetals of lactams and amides of acids. Communication 78. Synthesis and biological activity of 7,8-polymethylenepurine derivatives
Auteurs : D. B. Nilov [Russie] ; A. V. Kadushkin [Russie] ; I. F. Kerbnikova [Russie] ; I. S. Nikolaeva [Russie] ; V. V. Peters [Russie] ; T. A. Gus'Kova [Russie] ; R. A. Dubinskii [Russie] ; V. G. Granik [Russie]Source :
- Pharmaceutical Chemistry Journal [ 0091-150X ] ; 1995-02-01.
English descriptors
- Teeft :
- Acetic acid, Acetic anhydride, Acute toxicity, Amidine, Analgesic effect, Antiviral activity, Aqueous alcohol solution, Bubble size, Catalytic dehydration, Chemical properties, Compound viiie, Control experiment, Derivative, Elemental analysis data, Formic acid, Hypotensive effect, Hypoxanthine, Hypoxanthine derivatives, Hypoxanthine iiia, Hypoxanthine viiie, Internal administration, Intraperitoneal injection, Male mice, Methyl iodide, Mmole, Nitrogen gasometer, Painful irritation, Pyrimidine, Pyrimidine ring, Reaction mixture, Various amines, Viiia, Viiic, Viiie.
Abstract
Abstract: The condensation of diethylacetal of dimethylformamide with 4-amino-5-ethoxycarbonyl-1,2-polymethyleneimidazoles yielded derivatives of 7,8-polymethylenehypoxanthines that are precursors of 6-amino- and 6-alkylmercapto-7,8-polymethylenepurines and 1-substituted-7,8-polymethylenehypoxanthines. On the basis of the latter, 1,2-trimethylene-4,5,7,8-tetrahydro-6H-imidazo[4.5-e][1.4]diazepine-5,8-dione was obtained. The example of 6-substituted purines was used to study the antiviral activity, and 1-substituted purines were used to study the antihypertensive activity.
Url:
DOI: 10.1007/BF02226520
Affiliations:
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Nikolaeva</name><affiliation wicri:level="3"><country xml:lang="fr">Russie</country><wicri:regionArea>Chemical Drug Center - All-Russian Research Institute of Pharmaceutical Chemistry, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Peters, V V" sort="Peters, V V" uniqKey="Peters V" first="V. V." last="Peters">V. V. Peters</name><affiliation wicri:level="3"><country xml:lang="fr">Russie</country><wicri:regionArea>Chemical Drug Center - All-Russian Research Institute of Pharmaceutical Chemistry, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Gus Kova, T A" sort="Gus Kova, T A" uniqKey="Gus Kova T" first="T. A." last="Gus'Kova">T. A. 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Granik</name><affiliation wicri:level="3"><country xml:lang="fr">Russie</country><wicri:regionArea>Chemical Drug Center - All-Russian Research Institute of Pharmaceutical Chemistry, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Pharmaceutical Chemistry Journal</title><title level="j" type="abbrev">Pharm Chem J</title><idno type="ISSN">0091-150X</idno><idno type="eISSN">1573-9031</idno><imprint><publisher>Kluwer Academic Publishers-Plenum Publishers</publisher><pubPlace>New York</pubPlace><date type="published" when="1995-02-01">1995-02-01</date><biblScope unit="volume">29</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="106">106</biblScope><biblScope unit="page" to="110">110</biblScope></imprint><idno type="ISSN">0091-150X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0091-150X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acetic acid</term><term>Acetic anhydride</term><term>Acute toxicity</term><term>Amidine</term><term>Analgesic effect</term><term>Antiviral activity</term><term>Aqueous alcohol solution</term><term>Bubble size</term><term>Catalytic dehydration</term><term>Chemical properties</term><term>Compound viiie</term><term>Control experiment</term><term>Derivative</term><term>Elemental analysis data</term><term>Formic acid</term><term>Hypotensive effect</term><term>Hypoxanthine</term><term>Hypoxanthine derivatives</term><term>Hypoxanthine iiia</term><term>Hypoxanthine viiie</term><term>Internal administration</term><term>Intraperitoneal injection</term><term>Male mice</term><term>Methyl iodide</term><term>Mmole</term><term>Nitrogen gasometer</term><term>Painful irritation</term><term>Pyrimidine</term><term>Pyrimidine ring</term><term>Reaction mixture</term><term>Various amines</term><term>Viiia</term><term>Viiic</term><term>Viiie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The condensation of diethylacetal of dimethylformamide with 4-amino-5-ethoxycarbonyl-1,2-polymethyleneimidazoles yielded derivatives of 7,8-polymethylenehypoxanthines that are precursors of 6-amino- and 6-alkylmercapto-7,8-polymethylenepurines and 1-substituted-7,8-polymethylenehypoxanthines. On the basis of the latter, 1,2-trimethylene-4,5,7,8-tetrahydro-6H-imidazo[4.5-e][1.4]diazepine-5,8-dione was obtained. The example of 6-substituted purines was used to study the antiviral activity, and 1-substituted purines were used to study the antihypertensive activity.</div></front></TEI><affiliations><list><country><li>Russie</li></country><region><li>District fédéral central</li></region><settlement><li>Moscou</li></settlement></list><tree><country name="Russie"><region name="District fédéral central"><name sortKey="Nilov, D B" sort="Nilov, D B" uniqKey="Nilov D" first="D. B." last="Nilov">D. B. Nilov</name></region><name sortKey="Dubinskii, R A" sort="Dubinskii, R A" uniqKey="Dubinskii R" first="R. A." last="Dubinskii">R. A. Dubinskii</name><name sortKey="Granik, V G" sort="Granik, V G" uniqKey="Granik V" first="V. G." last="Granik">V. G. Granik</name><name sortKey="Gus Kova, T A" sort="Gus Kova, T A" uniqKey="Gus Kova T" first="T. A." last="Gus'Kova">T. A. Gus'Kova</name><name sortKey="Kadushkin, A V" sort="Kadushkin, A V" uniqKey="Kadushkin A" first="A. V." last="Kadushkin">A. V. Kadushkin</name><name sortKey="Kerbnikova, I F" sort="Kerbnikova, I F" uniqKey="Kerbnikova I" first="I. F." last="Kerbnikova">I. F. Kerbnikova</name><name sortKey="Nikolaeva, I S" sort="Nikolaeva, I S" uniqKey="Nikolaeva I" first="I. S." last="Nikolaeva">I. S. Nikolaeva</name><name sortKey="Peters, V V" sort="Peters, V V" uniqKey="Peters V" first="V. V." last="Peters">V. V. Peters</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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